Event Details
Alfred E.Mann Department of Biomedical Engineering - Seminar series
Thu, May 01, 2025
9:30 AM - 10:30 AM
Location: DRB 145
Speaker: Feng Yan, M.D. , Chief Neurosurgeon at the Second Affiliated Hospital of Zhejiang University School of Medicine, and Associate Professor at Zhejiang University
Talk Title: CAR-T Cell Therapy in Glioma: Clinical Insights and Challenges."
Abstract: Glioblastoma(Glioma) is one of the most aggressive primary brain tumors, with a medianoverall survival of less than two years despite standard treatments. Theimmunosuppressivetumor microenvironment, antigen heterogeneity, and the bloodbrain barrier are significant hurdles that limit the efficacy of CAR-T cells in GBM. Innovative strategies, including multi-antigen targeting and combination therapies, are being explored to enhance CAR-T cell persistence and function within the tumor milieu. In this presentation, I will delve into the current state of CAR-T therapy for gliomas, share insights from recent clinical cases, and discuss the challenges that lie ahead. Our goal is to shed light on the path forward, aiming to improve therapeutic outcomes for patients battling these formidable tumors.
Biography: Dr. Feng Yan is Chief Neurosurgeon at the Second Affiliated Hospital of Zhejiang University School of Medicine, Ph.D. advisor, and Associate Professor at Zhejiang University. He also serves as Vice President of Huzhou Affiliated Hospital of Zhejiang University. Dr. Yan specializes in the surgical management of brain tumors, including gliomas, meningiomas, and vestibular schwannomas, with expertise in advanced microsurgical and minimally invasive techniques. His research currently centers on CAR-T therapy and related clinical trials, and he is the recipient of numerous grants from China’s National Natural Science Foundation, which are equivalent to R01 awards from the NIH in the US. He has completed visiting scholar fellowships at Massachusetts General Hospital, Harvard Medical School, and UCLA. His work has been published in leading journals such as Theranostics, Journal of Advanced Research, and J Neuroinflammation. Dr. Yan is an active member of the American Association of Neurological Surgeonsï¼AANSï¼and several national neurosurgical societies.
Host: Peter Yingxiao Wang- Chair of Alfred E. Mann Department of Biomedical Engineering