University of Southern California Department of Biomedical Engineering The USC Andrew and Erna Viterbi School of Engineering USC
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Cardiorespiratory Sleep Lab



Research


PNEUMA: Simulation of spontaneous cardiovascular variability

The group has developed and continues to extend a comprehensive cardiorespiratory control model, named “PNEUMA”, that allows the simulation of physiological responses to a wide variety of conditions, including the 24-hour sleep-wake cycle, hypoxia-induced periodic breathing, Cheyne-Stokes respiration in congestive heart failure, and obstructive sleep apnea. It can be used to investigate the effects of interventions such as hypercapnic or hypoxic gas administration, the Valsalva and Mueller maneuvers, and the application of continuous positive airway pressure or simple mechanical ventilation. PNEUMA is implemented using SIMULINK® (The Mathworks, Natick, MA).

PNEUMA simulation software can be downloaded from the Biomedical Simulations Resource website

Examples of recent publications in this area:

(a) Fan H, Khoo MCK. PNEUMA: a comprehensive cardiorespiratory model. Proc 2nd Joint EMBS-BMES Conference, p.1533-1534, 2002.

(b) Ivanova OV, Khoo MCK. Simulation of spontaneous cardiovascular variability using PNEUMA. Proc 26th Annual IEEE EMBS Conference, p.3901-3904, 2004.