Cardiorespiratory Sleep Lab
Research
Time-varying analysis of autonomic control during arousal from sleep in obstructive sleep apnea syndrome
The minimal model has also been extended for applicability to conditions under which the cardiovascular autonomic control system is in a time-varying state. Such conditions include the period immediately following transient arousal from sleep, as well as during the response to cold face stimulation. Studies from Dr. Khoo’s lab have shown that, in sleep apneics, the model components that are sympathetically mediated exhibit significantly less reactivity to input changes than the corresponding components in normal controls. In normals, sympathetic reactivity is also reduced in REM sleep vis-à-vis NREM sleep. More recently, we have refined the time-varying minimal model and applied it as a means for quantitative daytime assessment of autonomic function in children with sleep apnea.
Examples of recent publications in this area:
(a) Blasi, A, Jo J, Valladares E, Juarez R, Baydur A, Khoo MCK. Autonomic cardiovascular control following transient arousal from sleep: A time-varying closed-loop model. IEEE Trans. Biomed. Eng. 2006; 53:74-82.
(b) Blasi, A, Jo J, Valladares E, Juarez R, Baydur A, Khoo MCK. Time-varying analysis of autonomic control during arousal from sleep in obstructive sleep apnea syndrome. Proc 25th Annual EMBS Conference, p.350-353, 2003.
(c) Chaicharn J, Lin Z, Chen ML, Keens TG,Ward SLD, Khoo MCK. Time-varying closed-loop modeling of autonomic control in pediatric Obstructive Sleep Apnea Syndrome during cold face stimulation. Proc 28th Annual IEEE EMBS Conference, 2006
