Mary G. and Robert G. Lane Early Career Chair Associate Professor of Biomedical Engineering and Cardiovascular Medicine
MEMS and nano sensors, reactive nitric oxide (RNS) and reactive oxygen species (ROS), vascular endothelial dynamics, and molecular imaging of atherosclerotic lesions.
Office: DRB 172
Phone: (213) 740-7236
Fax: (213) 740-0343
Email:
hsiai@usc.edu
Selected Publications
PATENTS
2005 Micro Electrical Mechanical Systems (MEMS) shear stress sensors for cardiovascular diagnostics-novel backside wire bonding.
Patent Number: 7367237
Title: MEMS vascular sensor
Issue Date: 05/06/08
2007 Polymer-Based Cardiovascular Sensors (US Patent Application Serial No. 60/942,300)
REFEREED PUBLICATIONS
1. Yaghoubi S, Tang W, Wnag S, Reed J, Hsiai T, Detrano R, Brundage B. Off line assessment of atherosclerotic coronary calcium from electron beam tomograms. American Journal of Cardiac Imaging. 1995 Oct, 9(4): 231-6.
2. Detrano R, Hsiai T, Wang S, Puentes G, Fallavollita J, Shields P, Stanford W, Wolfiel C, Georgiou D, Budoff M, Reed J, Brundage B. Prognostic value of coronary calcification and angiographic stenoses in patients undergoing coronary angiography. Journal of the American College of Cardiology. 1996 Feb, 27(2):285-90.
3. Honda, H. M., Hsiai, T., Wortham, C. M., Chen, M., Lin, H., Navab, M., Demer. L. L. A Complex flow pattern of low shear stress and flow reversal promotes monocyte binding to endothelial cells. Atherosclerosis. 2001,158:385-390.
4. Hsiai T* Cho S. K., Reddy S, Hama S., Navab M., Demer L., Honda H, Ho, C. M. Pulsatile flow patterns regulate monocyte adhesion to endothelial cells in response to oxidized lipids. Arteriosclerosis Thrombosis & Vascular Biology. 2001, 21(11): 1770-1776.
5. Hsiai T*., Yang J. M., Cho S. K. Cho, Yang X., Tai Y. C., Ho C. M., Micromachined particle filters for low power consumption. Journal of Fluids Engineering. American Society of Mechanical Engineering, 2002, 124(4):1053-1056.
6. Hsiai T*., Cho S. K, Honda, H., Hama S., Navab M., Demer L., Ho C. M. Endothelial cell dynamics under pulsating flow: Significance of high- vs. low shear stress slew rates (¶t / ¶ t). Annals of Biomedical Engineering, 2002, Vol. 30(5), pp. 646-656.
7. Hsiai*, T. K., Ing, M., Hwang, J., Salazar, A., Cho, S. K., Wang, P., Ho, C. M., Endothelial Cells: The Living Sensors and Actuators, International Journal of Nonlinear Sciences and Numerical Simulation. 2002, 3:169-172.
8. Hsiai, T*., Ing, M., Salazar, A., Cho S. K., Wong, P., Hama S., Navab M, Demer, L., Ho, CM, Monocyte recruitment to endothelial cells in response to oscillatory shear stress. The FASEB Journal. 2003, Vol. 17:1648-1657.
9. Hwang, J., Ing, M., Salazar, A., Lassegue, B. Griendling, K. Navab, M. Sevanian, A., Hsiai*, T. Pulsatlile vs. Oscillatory Shear Stress Regulates NADPH Oxidase Subunit: Implication for Native LDL Oxidation. Circulation Research. 2003; 93:1225-1232.
10. Li, C., Lei, B., Tang, T., Zhang, D., Rouhanizadeh, M., Hsiai, T. and Zhou, C. Chemical Gating of In2O3 Nanowires by Organic and Bio molecules. Applied Physics Letter. 2003, Vol. 83(19), 2003: 014-6.
11. Hsiai, T*., Salazar, A., Ing, M. A., Cho, S. K., Wang, P. K., Navab, M., Demer, L., Ho, CM. Micro Sensors: Linking Inflammatory Responses with Oscillatory Shear Stress. Annals of Biomedical Engineering, 2004, Vol. 32(2): 189-201.
12. Rouhanizadeh M., Tang, T., Li, C., Soundararajan, G., Zhou, C., Hsiai, T*. Applying Indium Oxide Nanowire as Sensitive and Selective Redox Protein Sensors, Proceedings, IEEE Micro Electro Mechanical Systems MEMS, 2004, Vol. 1: 431-4.
13. Soundararajan, G., Rouhanizadeh, M., Yu, H. Kim, E. S., Hsiai*, T., MEMS Shear Stress Sensors for Microcirculation. Sensors and Actuators: A. Physical. 2005,118(1):25-32.
14. Li, C., Lei, B., Tang, T., Zhang, D., Rouhanizadeh, M., Hsiai, T. and Zhou, C. Complementary response of In2O3 nanowires and carbon nanotubes to low-density lipoprotein chemical gating. Applied Physics Letter. 86, 103903, 2005.
15. Rouhanizadeh, M., Lin, L., Ascara, D., Hsiai, T*., Spatial variations in Shear stress at low Reynolds number flow. Annals of Biomedical Engineering. 2005, 33(10):1425-1440.
16. Rouhanizadeh, M., Hwang,J., Marcu, L., Lasseque, B., Sevanian, A., Hsiai*, T., Ox-PAPC induces endothelial superoxide production: Implication of NADPH oxidase. Free Radical Biology & Medicine. December, 2005, 39(11): 1512-1522.
17. L. DeMaio, M. Rouhanizadeh, S. Reddy, A. Sevanian, J. Hwang, and T. Hsiai*. Oxidized phospholipids mediate occludin expression and phosphorylation in vascular endothelial cells. Am J Physiol Heart Circ Physiol. 2006 Feb;290(2):H674-83.
18. Juliana Hwang, Howard N. Hodis, T. Hsiai, Liana Asatryan and Alex Sevanian, Role of Annexin II in Estrogen-Induced Macrophage Matrix Metalloproteinase-9, Atherosclerosis. 2006, Nov,189(1):76-82.
19. Mahsa Rouhanizadeh, Gopikrishna Soundararajan, Diego Ascara, Ronalee Lo, Frederick Browand, T. Hsiai*, MEMS sensors to resolve spatial variations in shear stress in a 3-D bifurcation model. IEEE Sensors. February, 2006, 6(1):78-88.
20. Mahsa Rouhanizadeh, T., Li, C., Hwang, J., Zhou, C., Hsiai, T*, In2O3 Nanowire to differentiate native from oxidized LDL. Sensors and Actuators: B. Chemical. April, 2006, 114 (2): 788-798.
21. Hwang J, Rouhanizadeh. M, Hodis H. N., Sevanian A. Hsiai, T*., 17b-Estradiol Reverses Shear Stress-Mediated LDL Modifications. Free Radical Biology & Medicine, 2006 Aug 15;41(4):568-78. Epub 2006 Apr 26.
22. Lin, C. T., Tintut, Y., Lyman, A., Mack, W., Demer, L. L., Hsiai, T*. Mechanical Response of a Calcified Plaque Model to Fluid Shear Force. Ann Biomedical Eng.2006 Oct;34(10):1535-41.
23. Hsiai*, T., Rouhanizadeh, M., Hamilton, R., Lin, T., Correa, A., Cadenas, E., Barr, M., Hwang, J., Cadenas, E., Hazen, S. L., Oscillatory shear stress promotes nitrative and oxidative stress relative to pulsatile shear stress: A potential mechanism accounting for predilection of atherosclerosis prone regions in vascular bifurcations. Free Radical Biology & Medicine. February 2007; 42 (4): 519-529.
24. Cheng, G. Y., Cao, F., Krishnan, M., Huang, M., Li, Z., Xie, X., Sheikh, A., Hoyt, G., Robbins, R., Hsiai, T., Schneider, M., Wu, J., Positron Emission Tomography of Conditional Gene Activation in the Heart, Journal of Molecular and Cellular Cardiology 2007 Mar 24; [Epub ahead of print] PMID: 17467733 [PubMed - as supplied by publisher]
25. Tzung K. Hsiai*, Mechano-signal Transduction in Vascular Endothelial and Smooth Muscle Cells: The Role of Hemodynamic Forces, Am Journal of Physiol: Cell Physiol, 2008 Jan 9; [Epub ahead of print]
26. Lisong Ai, Mahsa Rouhanizadeh, Joseph C. Wu, Wakako Takabe, Hongyu Yu, Mohammad Alavi, Yi Chu, Jordan Miller, Donald D. Heistad, Tzung K. Hsiai*, Pulsatile and Oscillatory Shear Stress Influences Spatial Variations in Vascular Mn-SOD Expression: Implication for LDL Nitration , Am J Physiology:Cell Physiol . 2008 April 23. [Epub ahead of print]
27. Mahsa Rouhanizadeh, Hongyu Yu, Lisong Ai, Jennifer Xu, Tzung K. Hsiai*, Micro- and Nano-Scale Anemometry: Implication for Biomedical Applications in Encyclopedia of Micro- and Noano-Fluidics, Springer, 2007 (in press)
28. Hongyu Yu, Lisong Ai, Mahsa Rouhanizadeh, Tzung K. Hsiai*, Heterogeneous Nano Structures Description: Multiscale structures with NEMS and MEMS components in Bio-Inspired and Nano-Scale Integrated Computing. WileyPress, 2007(in press)
29. Tzung K. Hsiai* and Judith Berliner, Oxidative stress as regulators of atherosclerosis in murine models in Current Drug Targets. Bentham Science Publishing edited by Frank Castellino, 2007, Volume 8, No. 12.
30. Mahsa Rouhanizadeh, Wakako Takabe, Hongyu Yu, Lisong Ai, Tzung Hsiai*, Monitoring Oxidative Stress in Vascular Endothelial Cells in Response to Fluid Shear Stress: From Biochemical Analyses to Micro- and Nanotechnologies in Methods in Enzymology, Part F: Oxidative and Nitrosative Stress in Redox Regulation of Cell Signaling. Edited by Lester Packer and Enrique Cadenas. 2008, Volume 441:Nitric Oxide Part G” (in press).
31. Ryan T. Hamilton, Juliana Hwang, Tzung K. Hsiai*, LDL protein nitration: Implication for LDL Protein Unfolding, Archives of Biochemistry and Biophysics (accepted)
32. Hongyu Yu, L. Ai. L., Rouhanizadeh, M, Patel, D., E. S. Kim, Tzung K. Hsiai*, Flexible polymer sensors for In vivo intravascular shear stress analysis, IEEE/ASME Journal of Microelectromechanical Systems (accepted)
33. Hsiai, T. K., and Wu, J. Hemodynamic forces and embryonic stem cells, Current Cardiology Reviews (in review)
34. Ai, L., Hamilton, R., Khalsa, R., Darbandi, F., Jun, A., Bressler, S., Rouhanizadeh, M., Hsiai, T*., Temporal variations in mitochondria superoxide generation by oscillatory and pulsatile shear Stress: The role of JNK. Am J Physiol (in revision)
35. Mahsa Rouhanizadeh, Lisong Ai, Wakako Takabe, Tzung K. Hsiai*, Shear Stress Regulates Mitochondrial Membrane Potential via NO and MnSOD, ATVB (in revision)
36. Lisong Ai, Hongyu Yu, Sharon Hale, Wande Dai, Po-Ying Li, Rongsong Li, Robert Kloner, Tzung K. Hsiai, Real-Time Intravascular Shear Stress in Rabbit Abdominal Aorta. IEEE Medicine and Biology (In review)
* Correspondence author
BOOK REVIEW
Understanding the Human Machine: A Primer for Bioengineering. Series on Bioengineering & Biomedical Engineering-Vol. 4 by Max E. Valentinuzzi, Feb., 2004
Biomed Eng Online. 2005 Feb 10;4(1):8
BOOK
Shear Stress and Endothelial Cell Dynamics edited by Tzung Hsiai (USC) and Hanjoong Jo (Georgia Tech), World Scientific Publishing (in preparation)
CONFERENCE PAPERS
.
1. Hsiai T, Tsao T, Ho C H. MEMS-based thermal shear stress sensors to study endothelial cell dynamics. Micro Devices in Medicine and Biology, Cambridge Biomedical Engineering Institute, Silicon Valley, April 1999.
2. Hsiai T, Cho S K, Yang JM, Yang X, Tai Y, Ho CH. Creeping flow across MEMS filters for Bio-Separation. 2000 Annual Meeting of the Biomedical Engineering Society, Seattle, WA, October 2000.
3. Hsiai T, Cho, SK, Honda H, Hama S, Navab, M, Deme, L, Ho CH. Pulsatile Flow Slew Rates Modulate Endothelial Cell Remodeling. 2000 Annual Meeting of the Biomedical Engineering Society, Seattle, WA, October 2000.
4. Hsiai T, Cho SK,Hama S, Jin L, Navab M, Ho CH. MEMS Screen for early endothelialization and Smooth Muscle Cell Proliferation. 2000 Annual Meeting of the Biomedical Engineering Society, Seattle, WA, October 2000.
5. Hsiai T, Cho SK, Hama S, Jin L, Navab M, Fogelman, Ho CH. Pulsatile vs. oscillatory flow profiles induce opposite effects on monocyte binding to endothelialized glass surface. 2000 Annual Meeting of the Biomedical Engineering Society, Seattle, WA, October 2000.
6. Hsiai T, Cho SK, Honda H, Hama S, Jin L, Reddy S, Navab M, Demer L, Fogelman A, Ho CH. Pulsatile vs. oscillating flows induce an opposite effect on monocyte binding to ox-PAPC treated endothelial cells. American Heart Association 72nd Scientific Sessions, New Orleans, Louisiana, November 2000
7. Hsiai T, Cho SK, Hama H, Reddy S, Demer L, Fogelman A, Ho CH. Pulssatile flow profiles modulates MCP-1 mRNA expression in Ox-PAPC treated endothelial cells. American college of Cardiology 50th Annual Scientific Session, Orlando, Florida, March 2001
8. Hsiai T, Hwang T, Reddy, S, Navab, M, Ho, CH, MEMS DNA sensors to study differential levels of MCP-1 expression in response to pulsating flow. Experimental Biology 2001, Orlando, Florida, March 2001.
9. Hsiai T, Cho SK, Ho CH, Micro shear stress sensors to study endothelial cell dynamics. Annual Biomedical Engineering 2001, NC, October 2001.
10. Hsiai T., Ing M., Salazar A., Wong, P., Navab M., Ho C. M. Endothelial Cells: The Living Sensors and Actuators, International Journal of Nonlinear Sciences and Numerical Simulation, Proceedings of International Conference on Micro and Nano Systems, Vol. 3, pp. 169-172, 2002.
11. Hsiai T., Wong P., Ing M., Navab M., Reddy S., Demer L., Ho C. M. Bio-MEMS sensors for real-time shear stress on endothelial cell dynamics, Proceedings of the Second Joint Meeting of the IEEE Engineering in Medicine and Biology and the Biomedical Engineering Society, Huston, USA, 2002.
12. Hsiai T, Ing M. Navab, M., Reddy S., Ho, C. M. Microsensors to characterize shear stress regulating inflammatory responses in the arterial bifurcations, Proceedings of the Second Joint Meeting of the IEEE Engineering in Medicine and Biology and the Biomedical Engineering Society, Houston, USA, 2002.
13. Wong P K, Kwong C, Hsiai T, Ho, C. M. Cell Tracking Velocimetry for Monocyte/Endothelial Cell Interactions, Proceedings of the Second Joint Meeting of the IEEE Engineering in Medicine and Biology and the Biomedical Engineering Society, September, 2002.
14. Hsiai T, Wong, P, Navab M, Sevanian A. MEMS stress sensors to correlate biomechanical force and endothelial function at the arterial bifurcation. Oxygen Club of California Scientific Conference 2002, Santa Barbara, CA, February, 2002.
15. Hsiai T, Hama, S, Ing, M, Navab M, Reddy S. Pulsatile shear stress regulates inflammatory responses in the arterial bifurcations. 3rd Annual Conference Arteriosclerosis, Thrombosis and Vascular Biology, AHA, Salt Lake City, Utah, April, 2002
16. Hsiai T, Hwang J, Ing M, Reddy S, Navab M, Sevanian A. Native LDL Oxidation in Response to Pulsatile Flow: Implication for MCP-1 Expression, American Heart Association Scientific Sessions, Chicago, November, 2002
17. Hsiai T, Sung K. Cho, Michael Ing, Adler Salazar, Linda Demer, Chih-Ming Ho, Micro Transducers: Linking Shear Stress with Endothelial Cell Dynamics, World Congress for Chinese Biomedical Engineers, Taipei, Taiwan, 2002
18. Hsiai T, Ing M, Salazar A, Sevanian A, Pulsatile flow regulates the extent of LDL Oxidation, American College of Cardiology 52nd Annual Scientific Session, Chicago, March, 2003.
19. Hsiai T, Ing M, Salazar A, Sevanian A, Micor transducers to Profile Pulsatile Shear Stress with Vascular Inflammatory Responses, American College of Cardiology 52nd Annual Scientific Session, Chicago, March, 2003.
20. Hsiai T, Hwang J, Ing M, Reddy S, Navab M, Sevanian A. Flow Regulation of NADPH Oxidase Subunit Gp91phox: Implication for Native LDL Oxidation, American Heart Association-ATVB Scientific Sessions, Washington DC, May, 2003.
21. Mike Ing, Juliana Hwang, Alex Sevanian, Tzung K. Hsiai, Ox-PAPC increases superoxide production via NADPH oxidase subunit, Nox4. American Heart Association Scientific Sessions, Orlando, FL, November, 2003.
22. Josh Bross, Adler Salazar, Mike Ing, Juliana Hwang, Alex Sevanian, Tzung K. Hsiai, Pulsatile flow regulates NADPH oxidase subunits: Gp91phos and its homog, Nox4: Implication for superoxide production, American Heart Association Scientific Sessions, Orlando, FL, November, 2003.
23. Juliana Hwang, Mike Ing, Alex Sevanian, Tzung K. Hsiai, Pulsatile flow regulates the relative production of reactive oxygen and reactive nitrogen species, American Heart Association Scientific Sessions, Orlando, FL, November, 2003.
24. Mahsa Rouhanizadeh, Tao Tang, Chao Li, Gopikrishnan Soundararajan, Chongwu Zhou, and Tzung K. Hsiai, Applying Indium Oxide Nanowires as Sensitive and Selective Redox Protein Sensors, Foresight Nanoinstitute, 2003
25. Josh Bross, Juliana Hwang, Michael Ing, Alex Sevanoian, Tzung Hsiai, Flow regulation of LDLL and akt phosphorylation, OCC, Santa Barbara, March, 2004
26. Juliana Hwang, Josh Bross, Micahel Ing, Alex Sevanian, Tzung K. Hsiai, Estradiol reverses oscillatory flow-induced LDL oxidation, OCC, Santa Barara, 2004
27. Josh Bross, Juliana Hwang, Alex Sevaian, Tzung Hsiai, Flow regulation of AKT phosphorylation, Federation of American Society of Experimental Biology, FASEB, Washington DC, April, 2004
28. Micahel Ing, Juliana Hwang, Lucas DeMaio, Josh Bross, Alex Sevanian, Tzung Hsiai, OxPAPC induces NADPH oxidase subunit, Nos4: Implication for NADPH autofluorescence and MMP, American Heart Association ATVB, San Francisco, May, 2004
29. Juliana Hwang, Josh Bross, Alex Sevanian, Tzung Hsiai, Estrogen reverses flow induced LDL oxidation via Nox4, American Heart Association ATVB, San Francisco, May, 2004
30. Lucas Demaio, Alex Sevanian, Tzung Hsiai, OxPAPC regulates tight junction protein, occludin, implication for endothelial cell permeability, American Heart Association ATVB, San Francisco, May, 2004
31. Josh Bross, Julian Hwang, Michael Ing, Alex Sevanian, Tzung Hsiai, Flow Regulation of LDL oxidation, International Vascular Biology Conference, Toronto, Canada, June, 2004.
32. Gopikrishnan Soundararajan, Mahsa Rouhanizadeh, Lucas DeMaio, and Tzung K. Hsiai, MEMS Shear stress sensors for cardiovascular diagnostics, IEEE Medicine and Biology, San Francisco, 2004.
33. Mahsa Rouhanizadeh, Tao Tang, Chao Li, Chongwu Zhou and Tzung Hsiai, Detection of Oxidized Low Density Lipoproteins by Indium Oxide Nanowires-Based Field Effect Transistor, IEEE Medicine and Biology, San Francisco, 2004.
34. Hsiai, T. A Dynamic Flow Model to Study Vascular Oxidative Stress, American Society of Clinical Investigation, Chicago, Aril, 2005
35. Hsiai, A. MEMS Sensors to resolve spatial variations in shear stress. IEEE ROBIO. Hong Kong, June, 2005
36. Chrisitna Lin, Mahsa Rouhanizadeh,Juliana Hwang, Tzung Hsiai, Oscillatory shear stress promotes reactive oxygen and reactive nitrogen species relative to pulsaitle flow: A potential mechanism for atherosclerotic prone regions within vascular bifurcations. Bionanoinformatic Fusion, 2005
37. Mahsa Rouhanizadeh, Christina Lin, Juliana Hwang, Tzung Hsiai, 17-estradiol attenuates oscillatory shear stress-indeuced LDL oxidation, Bionanoinformatic Fusion, 2005
38. DeMaio, L, Rouhanizadeh, M, Reddy, S., hwang, J., Tzung Hsiai, Oxidized phospholipids mediate occluding expression and phosphorylation in vascular endothelial cells, Baltimore, BMES-2005
39. Hsiai, T., Hwang, J. Hazen, S., Sevanian, S., Shear stress influences nitrative and oxidative modification of low density lipoprotein, Baltimore, BMES-2005
40. Lin, Tiantian , Yin, T., Demer, L. Hsiai, T. Fluid Shear Stress Destabilizes the Vascular Mesenchymal Stem Cells-Derived Calcifying Nodules, North American Vascular Biology Organization: Hemodynamic Influence on Pathogenesis, EXPERIMENTAL BIOLOGY 2006, San Francisco, CA
41. Rouhanizadeh, Mahsa, Miller, J. Heistad, D., Hsiai, T., Induction of BMP4 in Vascular Smooth Muscle Cells by Shear Stress, EXPERIMENTAL BIOLOGY 2006, San Francisco, CA
42. Rouhanizadeh, Mahsa, Yi, X., Heistad, D., Hsiai, T., Spatial variations regulation of expression of CuZn-SOD and Mn-SOD by shear stress in vascular tissue, EXPERIMENTAL BIOLOGY 2006, San Francisco, CA.
43. Hwang, J. Hsiai, T. 17b-estradiol modulates shear stress-mediated LDL modification. American Society of Clinical Investigation, Chicago, April, 2006
44. Rouhanizadeh, M., Hsiai, T. Flow regulation of vascular Mn SOD. AHA Atherosclerosis, Thrombosis, and Vascular Biology Meeting, Denver, Colorado, April, 2006
45. Hsiai, T., Rouhanizadeh, M., Barr, M., Correa, A., Alavi, M., Cadenas, E., Hwang, J., Hazen, S. L., Oscillatory shear stress promotes nitrative stress relative to pulsatile shear stress: A potential mechanism for athero-prone regions within vascular bifurcations. IEEE EMB, New York City, August, 2006.
46. Hsiai, T., Rouhanizadeh, M., Hwang, J., 17b-estradiol reverse shear stress-mediated LSL modifications, Annual Meeting for the Society of Biomedical Engineering, Chicago, October, 2006.
47. Hsiai, T, Rouhanizadeh, M., Hwang, J., Alavi M., Cadenas, E., Hazen, S., Spatial variations in shear stress regulates vascular oxidative stress, American Heart Association Scientific Sessions, Chicago, November, 2006.
48. Lisong Ai, Tzung K. Hsiai, Catheter-mediated effect on real-time wall shear stress measurement with Bio-MEMS sensors, FASEB, Washington DC, May, 2007
49. Ryan T. Hamilton, Tatsuya Sawamura, Juliana Hwang, Qiongqiong Zhou, Judith A. Berliner, Enrique Cadenas, Tzung K. Hsiai, Modified LDL Activates JNK-2 phosphorylation and p-JNK-2 Colocalizes with Mitochondria, ATVB, Chicago, 2007
50. Ryan T. Hamilton, Tzung K. Hsiai, LDL nitration induced protein unfolding, FASEB, Washington DC, +April, 2006
51. Ryan T. Hamilton, Tzung K. Hsiai, Modified LDL activates JNK-2 phosphorylation and colocalization with mitochondria, FASEB, Washington DC, May, 2007
52. Mahsa Rouhanizadeh, Meng-Tse Chen, Enrique Cadenas, Tzung K. Hsiai, Oscillatory and pulsatile Shear Stress Differentially Influences Mitochondrial Membrane Potential, FASEB, Washington DC, April, 2007
53. Enrique Cadenas, Tzung Hsiai, Effect of Oscillatory and Pulsatile Shear Stress on Mitochondrial Membrane potential of Endothelial Cells, ATVB, Chicago, April, 2007
54. Rouhanazadeh, M., Cadenas, E., Hsiai, T., Implication of Shear Stress on Mitochondrial Membrane Potential, ATVB, Chicago, April, 2007.
55. H. Yu, L. Ai, M. Rouhanizadeh, R. Hamilton, J. Hwang, E. Meng, E.S. Kim and T.K. Hsiai, “Polymer-Based Cardiovascular Shear Stress Sensors,” ASME Frontiers in Biomedical Devices Conference, Irvine, CA, June 7-8, 2007, BioMed2007-38089.
56. Yu, Hongyu, Kim, E.S., Hsiai, Tzung, Polymer-based Flexible Cardiovascular Shear Stress Sensors, 7th IEEE International Conference on Nanotechnology, Hong Kong, August, 2007.
57. Rouhanazadeh, M., Ai, L., Hamilton, R., Cadenas, E., Hsiai, T., Pulsatile and Oscillatory Shear Stress Regulates Endothelial Mitochondrial Redox State, Arteriosclerosis, Thrombosis, and Vascular Biology, Chicago, April, 2007
58. Lisong Ai1,a, Ryan T. Hamilton1,2,a, Enrique Cadenas1, Tzung K. Hsiai, Oscillatory and Pulsatile Shear Stress Differentially Induce p-JNK-2 Colocalization with Mitochondria, BMES 2007, Los Angeles, CA, September, 2007
59. Lisong Ai, Hongyu Yu, Tzung K. Hsiai, Simulation of Wall Shear Stress with Polymer-Based Flexible Sensors in Arterial Circulation, BMES 2007, Los Angeles, CA, September, 2007
60. Hongyu Yu, Lisong Ai, Mahsa Rouhanizadeh, Xiaotun Qiu, Robert Kloner, Eun Sok Kim, Tzung K. Hsiai, Flexible Catheter-Based Cardiovascular Shear Stress Sensors, BMES 2007, Los Angeles, September, 2007
61. Rouhanazadeh, M., Ai, L., Hamilton, R., Cadenas, E., Hsiai, T., Shear Stress Modulates Endothelial Mitochondrial Membrane Potential via NO Signaling, American Heart Association Scientific Sessions, Orlando, November, 2007
62. Hongyu Yu, Rouhanizadeh, R. A. Kloner, E. S. Kim. Tzung Hsiai, Flexible Shear Stress Sensors for Intravascular Testing, Hilton Head 2008 Solid-State Sensors, Actuators & Microsystems Workshop. Hilton Head, South Carolina, 2008.
INVITED LECTURES
1. Cardiovascular Grand Round, Division of Cardiovascular Medicine, Keck School of Medicine, University of Southern California, March, 2002.
2. Molecular Imaging, Department of Radiology, Keck School of Medicine, University of Southern California, May, 2002.
3. International MEMS and Nano Conference, Kuming, China, August, 2002
4. World Congress Biomedical Engineering Conference, Taipei, Taiwan, December, 2002
5. The Chinese University of Hong Kong, Hong Kong, December, 2002
6. Hong Kong Chinese University of Science & Technology, December, 2002
7. Johns Hopkins University, Department of Mechanical Engineering and Whitaker Biomedical Institute, May 2003
8. UCLA School of Medicine, Vascular Biology, Department of Medicine, July, 2003
9. UCSD, Department of Bioengineering, July 2003
10. California Institute of Technology, DARPA/DSO Symposium and Workshop on “Real-Time Monitoring Signaling Pathways in Biological Cells”, July 2003
11. IEEE International IEEE/RSJ IROS (International Robotic Society), Sensing and Manipulation of Micro Entities: Sciences, Engineering and Applications, Las Vegas, Oct. 2003
12. California Institute of Technology, Workshop on Shear Stress Sensing Technique and Measurement Results, Pasadena, February 5, 2004
13. Cardiology Grand Rounds, Division of Cardiovascular Medicine, University of Pittsburgh, March, 2004
14. 1st US-China Nanoscience and Nanotechnology Symposium, Beijing, China, May, 2004.
15. BioNEMS Symposium on Nanoscience and Nanotechnology: Implication for Cardiovascular Medicine, USC, May, 2004
16. ICSA 2004 Applied Statistics Symposium, June 6-9, 2004, San Diego, California
17. IEEE-EMBS Biomedical Engineering Chapter, Aug. 28, 2004, Thousand Oak, California
18. Department of Chemical Engineering, University of Southern California, September, 2004
19. Department of Electrical Engineering, California State University Northridge, October, 2004
20. Scientific Organizing Committee of the Los Angeles Tissue Engineering Initiative (LATEI), 2004 Annual Meeting, December, 2004
21. UCLA Bioengineering Symposium, January, 2005.
22. Department of Cardiology, University of Texas, Huston, MD Anderson Cancer Center, January, 2005
23. American Society of Clinical Investigation, Chicago, April 2005
24. Shanghai Jiatong University, Shanghai, China, May, 2005
25. Division of Cardiology, College of Medicine, University of Iowa, May, 2005
26. Department of Mechanical & Aerospace Engineering, Chinese University of Hong Kong, Hong Kong, China, June, 2005
27. Department of Cell Biology, Department of Biomedical Engineering, and Department of Cardiovascular Medicine, Title: Spatial variations in shear stress regulate vascular oxidative stress, The Cleveland Clinic Foundation, Cleveland, Ohio, March, 2006.
26. University of California System Bioengineering Symposium, UCLA, Los Angeles, June, 2006.
29. Federation of Analytical Chemistry and Spectroscopy Societies, Bioelectronics and Biosensors, The 3rd FACSS, FL, September 24-28, 2006.
30. Division of Cardiology Grand Rounds, College of Medicine, Cornell University, New York City, November, 2006
31. Los Angeles Tissue Engineering Initiative, School of Engineering, UCLA, Los Angeles, December, 2006
32. STAR Fellowship, School of Medicine, UCLA, Los Angeles, December, 2006
33. Dartmouth Hitchcock Medical Center, Dartmouth University, Hanover, NH, February, 2007
34. School of Medicine, Yale University, New Haven, Connecticut, April, 2007
35. Department of Bioengineering, UCLA School of Engineering & Applied Sciences, November, 2007
36. Bio-X Program, Frontier in Interdisciplinary Biomedical Sciences, Stanford University, February, 2008.
37. MGH Cardiovascular Research Center, Harvard Medical School, March, 2008.
e-mail: jberliner@mednet.ucla.edu
