Professor of Biomedical Engineering
Chonette Chair in Biomedical Technology
Pharmacokinetic/pharmacodynamic systems analysis, systems biology of drug action, drug development.

Office: DRB 154
Phone: (213) 740-0341
Fax: (213) 740-0343
Email: dargenio@bmsr.usc.edu 

 

Selected Publications 

D'Argenio, D.Z. (ed.). Advance Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis Volume 3, Kluwer Acadmeic Publishers, Boston, 2004.

Holleran, J.L., Parise, R.A., Joseph, E., Eiseman, J.L., Covey, J.M., Glaze, E., Lyubimov, A.V., D'Argenio, D.Z. and M.J. Egorin Plasma. Pharmacokinetics, Oral Bioavailability, and Species Scaling of the DNA Methyl Trandferase Inhibitor Zebularine (NSC 309132), in Mice, Rats, and Rhesus Monkeys. Clin. Cancer Res. (in press).

Xu, L., Eiseman, J.L. Egorin, M.J and D.Z. D'Argenio. Physiologically-Based Pharmacokinetic and Molecular Pharmacodynamics of 17-(allyalamino)-17-demethoxygeldanamycin and its Active Metabolite in Tumor-Bearing Mice. Journal of Pharmacokinetics and Pharmacodynamics, 30:185-219, 2003.

Bading, J.R., Yoo, P.B., Fissekis, J.D., Alauddin, M.M., D'Argenio, D.Z. and P.S. Conti. Kinetic Modeling of 5-Fluorouracil Anabolism in Colorectal Adenocarcinoma: A Positron Emission Tomography Study in Rats. Cancer Research, 63:3667-3674, 2003.

Zamboni, W.C., D.Z. D'Argenio, C.F. Stewart, T. MacVittie, B.J. Delauter, A.M. Farese, D.M. Potter, N.M. Kubat, D. Tubergen and M.J. Egorin. Pharmacodynamic Model of Topotecan-Induced Time Course of Neutropenia. Clinical Cancer Research, 7:2301-2308, 2001.

Drusano, G.L., D.Z. D'Argenio, S.L. Preston, C. Barone, W. Symonds, S. LaFon, M. Rogers, W. Prince, A. Bye & J.A. Bilello. Use of drug effect interaction modeling with Monte Carlo simulation to examine the impact of dosing interval on the projected antiviral activity of the combination of Abacavir and Amprenavir. Antimicrobial Agents in Chemotherapy, 44:1655-1659, 2000.

Snyder, S., D.Z. D'Argenio, O. Weislow, J.A. Bilello & G.L. Drusano. The triple combination of indivavir, zidovudine plus lamivudine is highly synergistic. Antimicrobial Agents in Chemotherapy, 44:1051-1058, 2000.

D'Argenio, D.Z. & A. Schumitzky. ADAPT II User's Guide: Pharmacokinetic/Pharmacodynamic Systems Analysis Software. Biomedical Simulations Resource, Los Angeles, 1997.

D'Argenio, D.Z. (ed.). Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis Vol II. Plenum Press, New York, 1995.

D'Argenio, D.Z. (ed.) Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis, Vol. I. Plenum Press, New York, 1991.