Carbamino Compounds

Carbamino compounds are the combination of CO2 with terminal amine groups in blood protein of which the most important is the globin of hemoglobin.

CO2 dissolves much more rapidly in blood because it has much higher solubility property. The amount of CO2 dissolved can be as much as 10% of the CO2 transported. However, this is still not enough carry away the rapid build up of CO2 in tissue. Carbamino compounds help to facilitate transporting about 20-30% of CO2 to the outside environment (About 60% is transported by (HCO3) - system).

In the group of carbamino compound, hemoglobin plays the most important role at all. When CO2 is bounded to Hb, the combination is called carbaminohemoglobin. When Hb is reduced at the tissue level, it binds with CO2 more rapidly.

This reaction occurs:

In tissues after Hb has released O2, it has an increased ability to pick up CO2 and in the lung, as hemoglobin binds to O2, the Hb more readily releases CO2.

In all, carbamino compounds are very important in transporting CO2 from the tissue level. In all carbamino compounds, Hb plays the most important role.

Sample Problems:

What are carbamino compounds? Which carbamino compound is most important? State and explain the Haldane effect?

Answers:

carbamino compounds are blood proteins which binds with CO2 and facilitate CO2 transportation. The globin molecule of Hb is the most important protein involved in forming carbamino compounds.

For more information on this topic, please refer to West , page 77.

Also, check out the following links that may be helpful:

• U. of Az: Physiology Lecture #48
• PCO2 and alveolar ventilation
• And, as always, if you have questions, or if you can suggest a helpful link, please e-mail me.

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This page was written by Luan Tran, a student in this course.

BME 403 Pages maintained by the T.A., Douglas Miles.